Search Result

Pathways Recommended:	Neuronal Signaling JAK/STAT Signaling

Results for "

STAT3 signaling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Angiotensin-converting Enzyme (ACE) (3) Apoptosis (26) Arginase (1) Autophagy (4) Bacterial (4) Bcl-2 Family (2) Bcr-Abl (1) c-Myc (1) Caspase (1) COX (3) Dopamine Receptor (1) EGFR (1) Endogenous Metabolite (2) ERK (3) FAK (1) Formyl Peptide Receptor (FPR) (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) IKK (1) Insulin Receptor (1) Interleukin Related (3) JAK (10) Keap1-Nrf2 (1) MDM-2/p53 (1) MicroRNA (1) Microtubule/Tubulin (2) mTOR (1) NF-κB (7) NO Synthase (1) p38 MAPK (2) Parasite (2) PI3K (2) Pyruvate Kinase (1) Reactive Oxygen Species (2) ROCK (1) Sirtuin (3) Src (1) STAT (43) Survivin (1) TNF Receptor (1) Topoisomerase (1) VEGFR (1) Virus Protease (1) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (51) Cardiovascular Disease (7) Infection (6) Inflammation/Immunology (17) Metabolic Disease (2) Neurological Disease (2)

By Targets:

Akt (3)

Angiotensin-converting Enzyme (ACE) (3)

Apoptosis (26)

Arginase (1)

Autophagy (4)

Bacterial (4)

Bcl-2 Family (2)

Bcr-Abl (1)

c-Myc (1)

Caspase (1)

COX (3)

Dopamine Receptor (1)

EGFR (1)

Endogenous Metabolite (2)

ERK (3)

FAK (1)

Formyl Peptide Receptor (FPR) (1)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (1)

IKK (1)

Insulin Receptor (1)

Interleukin Related (3)

JAK (10)

Keap1-Nrf2 (1)

MDM-2/p53 (1)

MicroRNA (1)

Microtubule/Tubulin (2)

mTOR (1)

NF-κB (7)

NO Synthase (1)

p38 MAPK (2)

Parasite (2)

PI3K (2)

Pyruvate Kinase (1)

Reactive Oxygen Species (2)

ROCK (1)

Sirtuin (3)

Src (1)

STAT (43)

Survivin (1)

TNF Receptor (1)

Topoisomerase (1)

VEGFR (1)

Virus Protease (1)

Wnt (2)

β-catenin (2)

By Research Areas:

Cancer (51)

Cardiovascular Disease (7)

Infection (6)

Inflammation/Immunology (17)

Metabolic Disease (2)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: RGS Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151577

STAT3-SH2 domain inhibitor 1	STAT Apoptosis	Cancer
STAT3-SH2 domain inhibitor 1 is a potent *Src Homology 2 (SH2) Domain of STAT3* (STAT3-SH2 domain) inhibitor with a K_d** value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer .

HY-150538

STAT3-IN-12	STAT Apoptosis	Cancer
STAT3-IN-12 is a potent *STAT3* signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma .

HY-128588

STAT3-IN-3 4 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-3 is a potent and selective inhibitor of **signal transducer and activator of transcription 3 (STAT3)*, with anti-proliferative activity. STAT3-IN-3 induces apoptosis* in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research .

HY-111152

ML115

STAT Cancer

ML115 is a molecular probe of the signal transducer and activator of transcription (STAT3). ML115 is a STAT3 agonist .

ML115	STAT	Cancer
ML115 is a molecular probe of the signal transducer and activator of transcription (STAT3). ML115 is a STAT3 agonist .

HY-125170

Galiellalactone	STAT	Cancer
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of **STAT3 signaling, with an IC₅₀** of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer .

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking *STAT3* phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

HY-161351

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

HY-124858

SC99	STAT JAK Apoptosis	Cardiovascular Disease Cancer
SC99 is an orally active, selective *STAT3* inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities .

HY-N7674

Angoline 1 Publications Verification	STAT	Cancer
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

HY-N7674A

Angoline hydrochloride	STAT	Cancer
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

HY-100602

HJC0152

1 Publications Verification

STAT Apoptosis Cancer

HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

HJC0152 1 Publications Verification	STAT Apoptosis	Cancer
HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

HY-107595

SD-1008	JAK STAT Apoptosis	Cancer
SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway .

HY-145935

NT219	Insulin Receptor STAT	Cancer
NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and *STAT3. IRS1/2 and STAT3* are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases .

HY-N1356

Reticuline	JAK STAT NF-κB Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Reticuline shows anti-inflammatory effects through *JAK2/STAT3* and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .

HY-N1447

Ganoderic acid A 4 Publications Verification	Apoptosis Autophagy Endogenous Metabolite	Cancer
Ganoderic acid A can inhibit of the *JAK-STAT3* signaling pathway, also inhibit proliferation, viability, ROS.

HY-116278

HJC0149

STAT Cancer

HJC0149 is a potent and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) .

HJC0149	STAT	Cancer
HJC0149 is a potent and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) .

HY-N0635

Prim-O-glucosylcimifugin 2 Publications Verification	NO Synthase COX	Inflammation/Immunology
Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by through regulating JAK2/STAT3 signaling.

HY-N2312

Mogrol 1 Publications Verification	ERK STAT	Cancer
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and *STAT3* pathways, or reducing CREB activation and activating AMPK signaling.

HY-N6940

Prosapogenin A Progenin III	Apoptosis	Cancer
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

HY-N12473

25-Deacetylcucurbitacin A	JAK	Inflammation/Immunology
25-Deacetylcucurbitacin A is a Cucurbitane-Type triterpenoid and has the potential to be an anti-cancer agent and JAK/STAT3 signaling pathway inhibitor .

HY-155335

FPR2 agonist 3	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the *STAT3/SOCS3* signaling pathway .

HY-108417

Debio 0617B	STAT JAK Bcr-Abl	Cancer
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34 ⁺ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors .

HY-N8107

Matairesinol monoglucoside	Others	Others
Matairesinol monoglucoside, a lignan compound, exhibits low activity on *IFN-γ/STAT1* and *IL-6/STAT3* signaling pathways with inhibition ratio of 5.8% and 7.0%, respectively .

HY-156958

S-72	Microtubule/Tubulin STAT Apoptosis	Inflammation/Immunology
S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing *STAT3* signaling .

HY-N4127

3'-Demethylnobiletin	Src STAT	Cancer
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits . Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling .

HY-121418

Lusianthridin	c-Myc	Cancer
Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling .

HY-147187

MNK8	STAT Apoptosis Bcl-2 Family Survivin	Cancer
MNK8 is a potent *STAT3* (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells .

HY-125355

SEC	Apoptosis	Cancer
SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation .

HY-101021

Ascochlorin Ilicicolin D
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of *STAT3* signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity .

HY-N11501

7-epi-Isogarcinol	STAT Apoptosis	Cancer
7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. 7-epi-Isogarcinol blocks *STAT3* signaling pathway, to induce apoptosis and inhibit cell migration .

HY-N0560

Oroxylin A 5+ Cited Publications Baicalein 6-methyl ether; 6-Methoxybaicalein	HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease	Cancer
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .

HY-122506

Salviolone	STAT	Cancer
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .

HY-149266

THK01	ROCK	Cancer
THK01 is a potent ROCK2 inhibitor with IC₅₀ values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. THK01 inhibits breast cancer metastasis through the ROCK2-STAT3 signaling pathway. THK01 can be used in research of breast cancer .

HY-N2963

Broussonin E	ERK p38 MAPK JAK STAT TNF Receptor Interleukin Related COX Arginase	Inflammation/Immunology
Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing *JAK2-STAT3* signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis .

HY-123099

MS-1020	JAK	Cancer
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling .

HY-B0130

Perindopril 4 Publications Verification S-9490	Angiotensin-converting Enzyme (ACE) NF-κB STAT Sirtuin	Cardiovascular Disease Neurological Disease Cancer
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .

HY-B0130A

Perindopril erbumine 4 Publications Verification Perindopril tert-butylamine salt; S-9490 erbumine	Sirtuin NF-κB STAT Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and *STAT3* signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .

HY-148615

NPD10084	Pyruvate Kinase	Cancer
NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo .

HY-N0177

Diosgenin 4 Publications Verification	STAT MicroRNA	Metabolic Disease
Diosgenin, a steroidal saponin, can inhibit *STAT3* signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .

HY-119767

Jolkinolide A	VEGFR Apoptosis	Cancer
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the *Akt-STAT3-mTOR* signaling pathway and reduces the expression of VEGF in A549 cells .

HY-N0751

Scutellarin Maximum Cited Publications 9 Publications Verification	STAT Akt HIV	Infection Cancer
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the *STAT3/Girdin/Akt* signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-N3149A

2-Hydroxycinnamaldehyde	Wnt β-catenin STAT Apoptosis	Inflammation/Immunology
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, *STAT3* signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-N6843

Arnicolide D 1 Publications Verification	Caspase PI3K Akt mTOR STAT	Cancer
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and *STAT3* signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner .

HY-N0678

Icaritin 1 Publications Verification Anhydroicaritin	Autophagy Apoptosis	Cancer
Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC₅₀ of 8 µM) and primary CML cells (IC₅₀ of 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis ^[3.

HY-N0279

Cardamonin Maximum Cited Publications 9 Publications Verification Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, *STAT3, Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-100037

NT157 1 Publications Verification Tyrphostin NT157
NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets *Stat3* signaling pathway .

HY-N2409

Delphinidin chloride	Apoptosis EGFR JAK STAT	Cardiovascular Disease Cancer
Delphinidin chloride is an anthocyanin isolated from berries and red wine. Delphinidin chloride exhibits endothelium-dependent vasodilation and anticancer activity. Delphinidin chloride also modulates *JAK/STAT3* and MAPK signaling, thereby inducing apoptosis in HCT116 cells. Delphinidin chloride is also a potent inhibitor of EGFR (IC₅₀: 1.3 μM), shutting down downstream signaling cascades .

HY-N3149

(E)-2-Hydroxycinnamaldehyde	STAT Apoptosis Reactive Oxygen Species	Cancer
(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be separated from the stem bark of cinnamon. (E)-2-Hydroxycinnamaldehyde inhibits cell proliferation and induces apoptosis by inhibiting signal transduction of *STAT3* and reactive oxygen species production. (E)-2-Hydroxycinnamaldehyde has antitumor activity .

HY-N1356A

(R)-Reticuline	Others	Inflammation/Immunology
(R)-Reticuline is an isomer of Reticuline (HY-N1356). Reticuline displays anti-inflammatory and cardiovascular effects through JAK2/STAT3 and NF-κB signaling pathways. Salutaridine is a key intermediate in morphine biosynthesis. Salutaridine can be converted from (R)-Reticuline in the poppy plant. The conversion system relies on membrane-bound cytochrome P-450 enzymes and also requires reducing cofactors NADPH, molecular oxygen, etc .

HY-B0130AR

Perindopril erbumine (Standard) Perindopril tert-butylamine salt (Standard); S-9490 erbumine (Standard)	Sirtuin NF-κB STAT Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Perindopril (erbumine) (Standard) is the analytical standard of Perindopril (erbumine). This product is intended for research and analytical applications. Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and *STAT3* signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks